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COVID-19 drugs: Are there any that work?

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Tháng Hai 17, 2022
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COVID-19 drugs: Are there any that work?
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  • I’ve heard several drugs mentioned as possible treatments for COVID-19. What are they and how do they work?
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I’ve heard several drugs mentioned as possible treatments for COVID-19. What are they and how do they work?

Answer From Daniel C. DeSimone, M.D.

There is only one approved by the U.S. Food and Drug Administration (FDA) to treat coronavirus disease 2019 (COVID-19). But many medications are being tested.

The FDA has approved an antiviral drug called remdesivir (Veklury) to treat COVID-19 in adults and children who are age 12 and older. Remdesivir may be prescribed for people who are hospitalized with COVID-19 and need supplemental oxygen or have a higher risk of serious illness. It’s given through a needle in the skin (intravenously).

See more: Covid 19 drugs

The FDA has authorized for emergency use a drug called Paxlovid. This drug combines two types of medications in one package. The first drug is nirmatrelvir. It blocks the activity of a specific enzyme needed for the virus that causes COVID-19 to replicate. The second drug is an antiviral drug called ritonavir. It helps slow the breakdown of nirmatrelvir. Paxlovid is authorized to treat mild to moderate COVID-19 in people age 12 and older who are at higher risk of serious illness. The medications are taken by mouth as pills.

The FDA has authorized for emergency use another drug called molnupiravir to treat mild to moderate COVID-19 in adults who are at higher risk of serious illness and not able to take other treatments. The medication is taken by mouth as a pill.

The FDA has authorized for emergency use the rheumatoid arthritis drug baricitinib (Olumiant) to treat COVID-19 in some cases. Baricitinib is a pill that seems to work against COVID-19 by reducing inflammation and having antiviral activity. Baricitinib may be used in people who are hospitalized with COVID-19 who are on mechanical ventilators or need supplemental oxygen.

Researchers are studying other potential treatments for COVID-19, including:

  • Antiviral drugs. Researchers are testing the antiviral drugs favipiravir and merimepodib. Studies have found that the combination of lopinavir and ritonavir isn’t effective.
  • Anti-inflammatory therapy. Researchers study many anti-inflammatory drugs to treat or prevent dysfunction of several organs and lung injury from infection-associated inflammation.
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    Dexamethasone. The corticosteroid dexamethasone is one type of anti-inflammatory drug that researchers are studying to treat or prevent organ dysfunction and lung injury from inflammation. Studies have found that this drug reduces the risk of death by about 30% for people on ventilators and by about 20% for people who need supplemental oxygen.

    The U.S. National Institutes of Health has recommended dexamethasone for people hospitalized with COVID-19 who are on mechanical ventilators or need supplemental oxygen. If dexamethasone isn’t available, other corticosteroids, such as prednisone, methylprednisolone or hydrocortisone, may be used. Dexamethasone and other corticosteroids may be harmful if given for less severe COVID-19 infection.

    In some cases, the drugs remdesivir, tocilizumab or baricitinib may be given with dexamethasone in hospitalized people who are on mechanical ventilators or need supplemental oxygen.

  • Immune-based therapy. Researchers study immune-based therapies, including convalescent plasma, mesenchymal stem cells and monoclonal antibodies. Monoclonal antibodies are proteins created in a lab that can help the immune system fight off viruses.

    Monoclonal antibody medications include sotrovimab; a combination of bamlanivimab and etesevimab; and a combination of casirivimab and imdevimab. These drugs are used to treat mild to moderate COVID-19 in people who have a higher risk of developing serious illness due to COVID-19. Treatment involves a single infusion given by a needle in the arm (intravenously) in an outpatient setting. To be most effective, these medications need to be given soon after COVID-19 symptoms start and before hospitalization. Some monoclonal antibodies are less effective against certain COVID-19 variants.

    Researchers also study the use of a type of immune-based therapy called convalescent plasma. The FDA has authorized for emergency use convalescent plasma therapy to treat COVID-19. Convalescent plasma is blood donated by people who’ve recovered from COVID-19. Convalescent plasma with high antibodies may be used to treat some hospitalized people with COVID-19 who are either early in their illness or have weakened immune systems.

  • Drugs being studied that have uncertain effectiveness. Researchers study amlodipine and losartan. But it’s not yet known how effective these drugs may be in treating or preventing COVID-19. Famotidine isn’t thought to be beneficial in treating COVID-19.
  • Ivermectin. The drug ivermectin, used to treat or prevent parasites in animals and in humans, isn’t a drug used to treat viruses. The FDA hasn’t approved use of this drug to treat or prevent COVID-19. Taking large doses of this drug can cause serious harm. Don’t use medications intended for animals on yourself to treat or prevent COVID-19.
  • Hydroxychloroquine and chloroquine. These malaria drugs were authorized for emergency use by the FDA during the COVID-19 pandemic. However, the FDA withdrew that authorization when data analysis showed that the drugs are not effective for treating COVID-19. They can also cause serious heart problems.
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    Drugs to prevent COVID-19. Researchers are studying drugs to prevent COVID-19 before and after exposure to the virus.

    The FDA has authorized for emergency use the monoclonal antibody combination of casirivimab and imdevimab as well as bamlanivimab and etesevimab. They may be used to treat people at higher risk of serious illness who have recently been exposed to the COVID-19 virus or who are at high risk of exposure. People at high risk of exposure may include those living in nursing homes or prisons where others have recently been infected with the COVID-19 virus. This treatment is for people who aren’t fully vaccinated, or who are fully vaccinated but have a weakened immune system.

    The FDA has also authorized for emergency use the monoclonal antibody combination of tixagevimab and cilgavimab (Evusheld) to prevent COVID-19 in some people with weakened immune systems or a history of severe reactions to a COVID-19 vaccine.

It’s not known if any of these will prove to be effective against COVID-19. It’s critical to complete medical studies to determine whether any of these medications are effective against COVID-19.

Don’t try these medications without a prescription and your health care provider’s approval, even if you’ve heard that they may have promise. These drugs can have serious side effects. They’re reserved for people who are seriously ill and under a health care provider’s care.

With

Daniel C. DeSimone, M.D.

Danh mục: News

Nguồn: https://daypg.com
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Jan. 27, 2022 Show references

  1. Information for clinicians on investigational therapeutics for patients with COVID-19. Centers for Disease Control and Prevention. daypg.com/coronavirus/2019-ncov/hcp/therapeutic-options.html. Accessed April 21, 2020.
  2. Emergency use authorization. U.S. Food and Drug Administration. daypg.com/emergency-preparedness-and-response/mcm-legal-regulatory-and-policy-framework/emergency-use-authorization#coviddrugs. Accessed Dec. 22, 2021.
  3. AskMayoExpert. COVID-19: Inpatient management. Mayo Clinic; 2021.
  4. Kim AY, et al. Coronavirus disease 2019 (COVID-19): Management in adults. daypg.com/contents/search. Accessed Jan. 14, 2022.
  5. Giudicessi JR, et al. Urgent guidance for navigating and circumventing the QTc-prolonging and torsadogenic potential of possible pharmacotherapies for coronavirus disease 19 (COVID-19). Mayo Clinic Proceedings. 2020; doi:10.1016/j.mayocp.2020.03.024.
  6. Coronavirus disease 2019 (COVID-19) treatment guidelines. National Institutes of Health. daypg.com/introduction/. Accessed Jan. 14, 2022.
  7. Coronavirus disease 2019 (COVID-19) frequently asked questions. U.S. Food and Drug Administration. daypg.com/emergency-preparedness-and-response/coronavirus-disease-2019-covid-19/coronavirus-disease-2019-covid-19-frequently-asked-questions. Accessed April 23, 2020.
  8. Zhang L, et al. Calcium channel blocker amlodipine besylate is associated with reduced case fatality rate of COVID-19 patients with hypertension. Medrxiv. 2020; doi:10.1101/2020.04.08.20047134.
  9. Marshall WF III (expert opinion). Mayo Clinic. Nov. 23, 2020.
  10. Q&A: Dexamethasone and COVID-19. World Health Organization. daypg.com/emergencies/diseases/novel-coronavirus-2019/question-and-answers-hub/q-a-detail/q-a-dexamethasone-and-covid-19. Accessed June 30, 2020.
  11. Horby P, et al. Effect of dexamethasone in hospitalized patients with COVID-19: Preliminary report. medRxiv. 2020; doi:10.1101/2020.06.22.20137273.
  12. Janowitz T, et al. Famotidine use and quantitative symptom tracking for COVID-19 in non-hospitalised patients: A case series. Gut. 2020; doi:10.1136/gutjnl- 2020- 321852.
  13. Why you should not use ivermectin to treat or prevent COVID-19. U.S. Food and Drug Administration. daypg.com/consumers/consumer-updates/why-you-should-not-use-ivermectin-treat-or-prevent-covid-19. Accessed Jan. 13, 2022.
  14. Coronavirus (COVID-19) update: FDA authorizes new long-acting monoclonal antibodies for pre-exposure prevention of COVID-19 in certain individuals. U.S. Food and Drug Administration. daypg.com/news-events/press-announcements/coronavirus-covid-19-update-fda-authorizes-new-long-acting-monoclonal-antibodies-pre-exposure. Accessed Dec. 9, 2021.
  15. AskMayoExpert. COVID-19: Outpatient management (adult). Mayo Clinic. 2021.

See more Expert Answers

Products and Services

  1. U.S. COVID-19 Vaccine Tracker: See your state’s progress
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See also

  1. COVID-19 and vitamin D
  2. Convalescent plasma therapy
  3. Coronavirus disease 2019 (COVID-19)
  4. COVID-19: How can I protect myself?
  5. Cough
  6. Herd immunity and coronavirus
  7. COVID-19 and pets
  8. COVID-19 and your mental health
  9. COVID-19 antibody testing
  10. COVID-19, cold, allergies and the flu
  11. Long-term effects of COVID-19
  12. COVID-19 tests
  13. COVID-19 in babies and children
  14. COVID-19 travel advice
  15. COVID-19 vaccine: Should I reschedule my mammogram?
  16. COVID-19 vaccines for kids: What you need to know
  17. COVID-19 vaccines
  18. COVID-19 variant
  19. COVID-19 vs. flu: Similarities and differences
  20. COVID-19: Who’s at higher risk of serious symptoms?
  21. Debunking coronavirus myths
  22. Diarrhea
  23. Different COVID-19 vaccines
  24. Extracorporeal membrane oxygenation (ECMO)
  25. Fever
  26. Fever: First aid
  27. Fever treatment: Quick guide to treating a fever
  28. Honey: An effective cough remedy?
  29. How do COVID-19 antibody tests differ from diagnostic tests?
  30. How does COVID-19 affect people with diabetes?
  31. How to take your pulse
  32. How to measure your respiratory rate
  33. How to take your temperature
  34. How well do face masks protect against COVID-19?
  35. Loss of smell
  36. Mayo Clinic Minute: You’re washing your hands all wrong
  37. Mayo Clinic Minute: How dirty are common surfaces?
  38. Multisystem inflammatory syndrome in children (MIS-C)
  39. Nausea and vomiting
  40. Pregnancy and COVID-19
  41. Coronavirus infection by race
  42. Red eye
  43. Safe outdoor activities during the COVID-19 pandemic
  44. Safety tips for returning to school during COVID-19
  45. Sex and COVID-19
  46. Shortness of breath
  47. Thermometers: Understand the options
  48. Treating COVID-19 at home
  49. Unusual symptoms of coronavirus
  50. Watery eyes
  51. Fight coronavirus (COVID-19) transmission at home

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